Author/Authors :
Talebi, Ardeshir Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Karimi, Amirhossein Department of Nutrition, University of Nantes, Nantes, France , Ouguerram, Khadija Department of Nutrition, University of Nantes, Nantes, France , Vahidi-Ataabadi, Nasrin Department of Clinical Pathology - Isfahan University of Medical Sciences, Isfahan, Iran , Eshraghi-Jazi, Fatemeh Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Mansouri, Azam Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Nematbakhsh, Mehdi Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Background: Gentamicin (GM) is used as antibiotic for
Gram-negative infections, but its administration is limited due to a side-effect of nephrotoxicity. It was attempted to investigate the effect of Althaea officinalis flower extract (AOFE) against nephrotoxicity induced by GM in male rats.
Methods: 30-year-old male Wistar rats were divided into five groups. Group 1 as a negative control group received AOFE 250 mg/kg/day. Groups 2-5 received saline, AOFE 50 mg/kg/day, AOFE 250 mg/kg/day, and AOFE 500 mg/kg/day for 9 days, respectively, and GM (100 mg/kg/day) was added from the 3rd day on. At the end of the experiment, blood samples were obtained,
animals were sacrificed, and the kidneys were removed immediately.
Results: Gentamicin (in group 2) significantly increased serum levels of blood urea nitrogen and creatinine as well as the pathological damage score (P < 0.05) when compared with group 1. Low dose of AOFE did not decrease the nephrotoxicity induced by GM while the high dose of AOFE aggravated renal toxicity (P < 0.05).
Conclusions: Although AOFE acts as an antioxidant, at the doses used in the current study did not ameliorate nephrotoxicity induced by GM.
Keywords :
Gentamicin , Althaea officinalis , nephrotoxicity , rat
