Title of article :
Novel procedure for preparation of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
Author/Authors :
Ezabadi, Ali Department of Chemistry - Faculty of Sciences - Islamic Azad University Central Tehran Branch, Sanat Square, Iran , Tosan, Fatemeh Department of Chemistry - Faculty of Sciences - Islamic Azad University Central Tehran Branch, Sanat Square, Iran
Abstract :
An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.
Keywords :
ammonium acetate , ethyl acetoacetate , aldehydes , catalyst-free , three-component reaction , PEG-400 , Hantzsch 1 , 4 – dihydropyridines
Journal title :
Astroparticle Physics
