Author/Authors :
Ghammamy, Shahriar Department of Chemistry - Faculty of Science - Imam Khomeini International University, Ghazvin, Iran , Hosseinzadeh Khezri, Rozita Department of Chemistry - Faculty of Science - Imam Khomeini International University, Ghazvin, Iran , Amini, Zahra Department of Chemistry - Faculty of Science - Imam Khomeini International University, Ghazvin, Iran , Mirrahimi, Monir Al-sadat Department of Chemistry - Faculty of Science - Imam Khomeini International University, Ghazvin, Iran , Soleimani, Masoud Department of Hematology - Faculty of Medicine - Tarbiat Modarres University, Tehran, Iran , Kaniani, Saeid Department of Hematology - Faculty of Medicine - Tarbiat Modarres University, Tehran, Iran
Abstract :
In this research, some of the inorganic complexes of uranyl with N- donor ligands
were synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR,
¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center of
uranium atom with the charge (+6) and two oxygen atom by forming two U=O double bonds.
The structure is linear (O=U=O, 180) and usually stable. So other ligands often coordinate to
the U atom in the plane perpendicularly to the O=U=O axis. The antitumor activity of some of
ligand and their complexes against a panel of human tumor cell lines (HT29: Haman colon
adenocarcinoma cell line T47D: human breast adenocarcinoma cell line) were determined by
MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay. These data
suggest that some of these compounds provide good models for the further design of potent
antitumor compounds.
Keywords :
Anticancer Activity , Schiff bases , Uranyl complex-donor ligands , Inorganic
