Title of article :
Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives
Author/Authors :
Azizian, Javad Factually of Science - Islamic Azad University Science and Research Branch, Tehran, Iran , Miri, Ramin Medicinal & Natural Products Chemistry Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Mohammadi, Mohammad Kazem Factually of Science - Islamic Azad University Science and Research Branch, Tehran, Iran
Abstract :
Abstract - New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the construction of such heterocyclic ring systems.
Keywords :
Bielectrophile , Binucleophile , Pyrimido[4,5-e][1,3,4]thiadiazine , 5-Bromo-2,4-dichloro-6-methylpyrimidine , Heterocyclization
Journal title :
Astroparticle Physics
