Author/Authors :
Abbayya, Keshava Department of Periodontology - School of Dental Sciences - Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra , Zope, Sameer Anil Department of Periodontology - School of Dental Sciences - Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra , Naduwinmani, Sanjay Department of Orthodontics - Maratha Mandal Dental College, Belgaum, Karnataka , Pisal, Apurva Department of Periodontology - School of Dental Sciences - Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra , Puthanakar, Nagraj Department of Prosthodontics - A.C.P.M. Dental College, Dhule, Maharashtra, India
Abstract :
Periodontitis is a disease of the periodontium, characterized by loss of connective tissue attachment and supporting the alveolar bone. Therefore, to regenerate these lost tissues of the periodontium researchers have included a variety of surgical procedures including grafting materials growth
factors and the use of barrier membranes, ultimately resulting into regeneration that is biologically possible but clinically unpredictable. Recently a newer approach of delivering DNA plasmids as therapeutic agents is gaining special attention and is called gene delivery method. Gene therapy being considered a novel approach have a potential to channel their signals in a very systematic and controlled manner thereby providing encoded proteins at all stages of tissue regeneration. The aim of this review was to enlighten a view on the application involving gene delivery and tissue engineering in periodontal regeneration.
Keywords :
Gene , growth factors , periodontal regeneration , stem cells , tissue engineering , vectors
