Fabrication of a Selective and Sensitive Electrochemical Sensor Modified with Magnetic Molecularly Imprinted Polymer for Amoxicillin

In this work, a modified electrochemical sensor for the determination of amoxicillin (AMX) is introduced. A magnetic molecularly imprinted polymer (MMIP) was suspended in AMX solution and then collected on the surface of a magnetic carbon paste electrode (CPE) via a permanent magnet, situated within the carbon paste electrode, and then the voltammetry signals were recorded. It was confirmed that MMIP/CPE shows greater recognition ability than the magnetic non-molecularly imprinted (MNIP)/CPE. The influence of the operational parameters including pH, MMIP amount, extraction time and accumulation time was elucidated. The performance of the fabricated sensor was evaluated and the results indicated that the sensor has a high sensitivity in AMX detection, with a linear range from 0.0010-0.11 μM and a limit of detection of 0.26 nM. The MMIP/CPE is simple to fabricate and easy to use and was successfully applied to the determination of AMX in pharmaceutical samples with recoveries between 98.8 and 103.2%, without the need of a sample pre-treatment steps.