INTERLEUKIN 10 LNHIBITS TNF-ALPHA PRODUCTION IN HUMAN MONOCYTES INDEPENDENTLY OF INTERLEUKIN 12 AND INTERLEUKIN 1 BETA

For studying the influence of smoking on temporary threshold shift (TTS), six normal subjects (3 smokers and 3 nonsmokers) were selected for carrying out this work. Nonsmokers were exposed separately for 7 min to 95 dB SPL in 1/3-octave band filtered noise centred at 2 kHz. Pre and post exposure thresholds (leftear) were recorded in a sound-proof booth using Bruel &: Kjaer (B &, K) Audiometer type 1800. For smokers, each one smoked a cigarette during the five minutes following the pre-exposure threshold measurement. All the assessments were conducted at a temperature between 22 - 25°C. The results indicated that smokers evidenced less TTS than did nonsmokers in the frequency range from 1 kHz to 5 kHz. At 6 kHz smokers evidenced nearly higher value. Maximum TTS was attained at frequency that was about 1/2-octave higher than that of the exposed noise. Comparison between recovery curves for smokers and nonsmokers was also made. PACS numbers: 43.66