Author/Authors :
Geramizadeh, Bita Department of Pathology - Transplant Research Center - Shiraz University of Medical Sciences, Shiraz , Jowkar, Zahra Department of Pathology - Transplant Research Center - Shiraz University of Medical Sciences, Shiraz , Karami, Leila Department of Pathology - Transplant Research Center - Shiraz University of Medical Sciences, Shiraz , Masoumpour, Masoum Department of Internal Medicine - Shiraz University of Medical Sciences, Shiraz , Mehrabi, Samrad Department of Internal Medicine - Shiraz University of Medical Sciences, Shiraz , Ghayoumi, Mohammad-Ali Department of Internal Medicine - Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: Alpha-1 antitrypsin deficiency is a genetic disease which affects both lung and liver. This disease is a recognized factor for chronic obstructive pulmonary disease (COPD). However its importance as the cause of COPD in a country such as Iran is unclear.
Objectives: This study was conducted to find out the role of α-1 antitrypsin deficiency as a cause of COPD in Iranian patients.
Materials and Methods: The serum concentration of α-1 antitrypsin was determined and the genotype of α-1 antitrypsin was also evaluated by PCR-RFLP in 130 patients with COPD and 50 normal healthy blood donors.
Results: No α-1 antitrypsin deficient case was found in normal healthy people and COPD patients.
Conclusions: Our results clarify that deficiency of α-antitrypsin is not a major cause of COPD in Iranian patients.
