Title of article :
New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines
Author/Authors :
Vessally, Esmail Department of Chemistry - Payame Noor University - Tehran , Hosseinian, Akram Department of Engineering Science - College of Engineering - University of Tehran , Edjlali, Ladan Department of Chemistry - Tabriz Branch - Islamic Azad University - Tabriz , Babazadeh, Mirzaagha Department of Chemistry - Tabriz Branch - Islamic Azad University - Tabriz , Hosseinzadeh-Khanmiri, Rahim Department of Chemistry - Tabriz Branch - Islamic Azad University - Tabriz
Abstract :
Functionalized morpholines have attracted much attention due to their potential biological activities. Despite wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their synthesis remains relatively unexplored. Given the low cost and easy availability of N-propargylamines, the synthesis of functionalized morpholines from these versatile building blocks have undergone an explosive growth in recent years. This review provides concise overview on the synthesis of morpholine cores from N-propargyalamines in recent years.
Keywords :
Bridged systems , Cyclo-ketalization , 6-exo-dig cyclization , Morpholines , N-propargylamines
Journal title :
Astroparticle Physics
