Author/Authors :
Honarkar Shafie, Elaheh Department of Clinical Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Keshavarz, Ali Department of Clinical Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Kefayati, Mohammad Esmaiel Department of Applied Chemistry - Faculty of Chemistry - Amirkabir University of Technology, Tehran, Iran , Taheri, Fatemeh Department of Clinical Biochemistry - Faculty of Medical Sciences - Tarbiat Modares University, Tehran, Iran , Sarbakhsh, Parvin Department of Statistic and Epidemiology - Faculty of Nutrition and Health - Tabriz University of Medical Sciences, Tabriz, Iran , Vafa, Mohammad Reza Department of Nutrition - School of Public Health - Iran University of Medical Sciences, Tehran, Iran
Abstract :
Background: Ferrous sulfate is the most used supplement for treating anemia, but it can result in unfavorable side effects. Nowadays, nanotechnology is used as a way to increase bioavailability and decrease the side effects of drugs and nutrients. This study investigates the effects of nanoparticles containing iron on blood and inflammatory markers in comparison to ferrous sulfate in anemic rats.
Methods: To induce the model of hemolytic anemia, 50 mg/kg bw phenylhydrazine was injected intraperitoneally in rats on the 1st day and 25 mg/kg bw for the four following days. Then, rats were randomly divided into five groups. No material was added to the nipple of the Group 1 (control). Group 2 received 0.4 mg/day nanoparticles of iron; Group 3 received 0.4 mg/day ferrous sulfate, and Groups 4 and 5 received double dose of iron nanoparticle and ferrous sulfate, respectively for ten days.
Results: Hemoglobin and red blood cell (RBC) in Group 2 were significantly higher than Group 3 (P < 0.05). In addition, hemoglobin and RBC in Group 4 and 5 were significantly higher
than Group 3 (P < 0.05). The average level of serum iron in Groups 2 and 4 was remarkably more than the groups received ferrous sulfate with similar doses (P < 0.05). C‑reactive protein
in Group 3 was more than Group 2 and in Group 5 was more compare to all other groups.
Conclusions: Single dose of nanoparticles had more bioavailability compare to ferrous sulfate, but this did not occur for the double dose. Furthermore, both doses of nanoparticles caused lower inflammation than ferrous sulfate.
