Title of article :
SHORT PAPER Effect of captopril on TNF-α and IL-10 in the livers of Bile Duct ligated Rats
Author/Authors :
Amirshahrokhi, Keyvan Department of Pharmacology - School of Medicine - Tehran University of Medical Sciences - Tehran , Ghazi-khansari, Mahmoud Department of Pharmacology - School of Medicine - Tehran University of Medical Sciences - Tehran , Mohammadi- Farani, Ahmad Department of Pharmacology - School of Medicine - Tehran University of Medical Sciences - Tehran , Karimian, Golnar Department of Pharmacology - School of Medicine - Tehran University of Medical Sciences - Tehran
Abstract :
Background: The renin-angiotensin system has an important role in hepatic
inflammation and fibrosis. Renin-angiotensin system blockade by angiotensinconverting
enzyme (ACE) inhibitors provides some protective effects against hepatic
fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and
attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats. Objective: The
present study was conducted to investigate the effects of captopril on cytokine
production in hepatic fibrosis induced by a bile duct ligation model in rats. Methods:
Male rats were divided into four groups including; control, sham operated, BDL, and
BDL plus captopril (10 mg/kg/day, orally). After 28 days of treatment, the livers were
removed for cytokine analysis. Hepatic interleukin (IL)-10 and tumor necrosis factor
(TNF)-α levels were measured. Results: Captopril treatment decreased the hepatic
content of the proinflammatory cytokine TNF-α and increased the anti-inflammatory
cytokine IL-10. Conclusion: the present study suggests that the protective effect of
captopril on hepatic fibrosis is likely to be mediated by cytokine production.
Keywords :
TNF-α , IL-10 , Hepatic fibrosis , Captopril
Journal title :
Astroparticle Physics