Title of article :
Genistein Induces a Protective Immunomodulatory Effect in a Mouse Model of Cervical Cancer
Author/Authors :
Ghaemi, Amir Department of Microbiology - School of Medicine - Infectious Diseases research Centre - Golestan University of Medical Sciences - Gorgan , Tabaraei, Alijan Department of Microbiology - School of Medicine - Infectious Diseases research Centre - Golestan University of Medical Sciences - Gorgan , Moradi, Abdolvahab Department of Microbiology - School of Medicine - Infectious Diseases research Centre - Golestan University of Medical Sciences - Gorgan , Gorji, Ali Shefa Neuroscience Research Centre , Soleimanjahi, Hoorieh Department of Virology - Faculty of Medical Sciences - Tarbiat Modares University , Razeghi, Soodeh Sina Hospital - Tehran University of Medical Sciences - Tehran , Alizadeh, Akram Department of Advanced Technology - Tehran University of Medical Sciences - Tehran , Vakili, Mohammad Ali Department of Health and Social Sciences - Golestan University of Medical Sciences - Gorgan
Abstract :
Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has
attracted scientific interest for its possible benefits in cancer. Objective: The potential
immunomodulatory effects of genistein on the immune system and against TC-1 tumor
cell line were evaluated in adult female C57BL/6 mice. Methods: Mice were treated
with GEN 10 days before to 10 days after the tumor induction. Thirty days after the last
GEN treatment, lymphocyte proliferation, Lactase Dehydrogenase (LDH) cytolytic
activity and cytokine secretion were analyzed in GEN and control groups. Results: The
results showed that ingestion of genistein significantly increased lymphocyte
proliferation and LDH release. Furthermore, the treatment with genistein also caused a
significant increment in interferon gamma (IFN-γ). In addition, the treatment achieved
significant therapeutic effect in tumor models compared to the control group. These
results indicated that the effect of GEN on tumor growth may be attributed to its effect
on lymphocyte proliferation, cytolytic activity and IFN-γ production. Conclusion:
These results demonstrate that GEN exerts an immunomodulatory effect in a mouse
model of Human Papillomavirus (HPV) associated-cervical cancer.
Keywords :
Cervical Cancer , Genistein , TC-1 , Imunomodulation , Human Papillomavirus
Journal title :
Astroparticle Physics
