Title of article
SHORT PAPER Elevated Levels of Interleukin-23 in Sera of Patients with Pemphigus Vulgaris
Author/Authors
Pouralibaba, Firouz Tabriz University of Medical Sciences - Tabriz , Babaloo, Zohreh Tabriz University of Medical Sciences - Tabriz , Pakdel, Farzaneh Tabriz University of Medical Sciences - Tabriz , Abdollahian, Tahmoores Tabriz University of Medical Sciences - Tabriz , Pourzare, Solmaz Tabriz University of Medical Sciences - Tabriz
Pages
5
From page
261
To page
265
Abstract
Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most
prevalent type of pemphigus which manifests with development of bullae and erosions
on skin and mucosal membranes. Objectives: To investigate the potential role of IL-23
in pemphigus vulgaris. Methods: In this study, 30 patients with pemphigus vulgaris and
30 healthy individuals were selected according to inclusion and exclusion criteria.
Measurement of IL-23 serum levels in blood samples was conducted by ELISA. Data
was analyzed using Student’s t-test for comparison of IL-23 levels between the two
groups. Results: Mean serum levels of IL-23 in patients with pemphigus and healthy
controls were 25.1 ± 4.2 and 17.9 ± 4.7 pg/ml, respectively (p<0.05). Conclusions:
Based on the findings of this study, serum levels of IL-23 were higher in patients with
pemphigus in comparison to healthy individuals with no clinical significance.
Keywords
Pemphigus Vulgaris , Interleukin-23 , Autoimmune Disease
Journal title
Astroparticle Physics
Serial Year
2012
Record number
2429318
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