Author/Authors :
Ahmadi-Motamayel, Fatemeh Hamadan University of Medical Sciences - Hamadan , Bayat, Zeynab Hamadan University of Medical Sciences - Hamadan , Hajilooi, Mehrdad Hamadan University of Medical Sciences - Hamadan , Shahryar-Hesami, Soroosh Hamadan University of Medical Sciences - Hamadan , Mahdavinezhad, Ali Hamadan University of Medical Sciences - Hamadan , Samie, Lida Hamadan University of Medical Sciences - Hamadan , Solgi, Ghasem Hamadan University of Medical Sciences - Hamadan
Abstract :
Background: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be
considered as a potential premalignant status. Objective: To evaluate the miRNA-146a
and miRNA-155 expression levels in patients with oral Lichen planus lesions compared
to healthy subjects with normal oral mucosa. Methods: Forty patients with oral lichen
planus and 18 healthy age and gender-matched controls were recruited in this casecontrol
study. Oral lichen planus was diagnosed clinically and pathologically. The
expression levels of two miRNAs in peripheral blood samples were determined using
commercial TaqMan MicroRNA Assays. Relative quantification of gene expression was
calculated by the 2-ΔΔct method. Results: The expression levels of miRNA-146a and
miRNA-155 in patients with oral Lichen planus were significantly higher than the of the
healthy control group. Also, a direct but insignificant correlation was found between
miRNA-155 and miRNA-146a expression levels among the patient group. Conclusion:
Our findings indicate that miRNA-146a and miRNA-155 could be potential biomarkers
for the immunopathogenesis of oral lichen planus.
