Title of article :
SHORT PAPER IL-6/IL-10 Ratio as A Prognostic and Predictive Marker of the Severity of Inherited Epidermolysis Bullosa
Author/Authors :
Tampoia, Marilina Clinical Pathology Laboratory - Polyclinic of Bari - Department of Biomedical Sciences and Human Oncolog - University of Bari - Piazza Giulio Cesare 11 - 70124 Bari - Italy , Fumarulo, Ruggiero Clinical Pathology Laboratory - Polyclinic of Bari - Department of Biomedical Sciences and Human Oncolog - University of Bari - Piazza Giulio Cesare 11 - 70124 Bari - Italy , Morrone, Marella Clinical Pathology Laboratory - Polyclinic of Bari - Department of Biomedical Sciences and Human Oncolog - University of Bari - Piazza Giulio Cesare 11 - 70124 Bari - Italy , Abbracciavento, Letizia Clinical Pathology Laboratory - Polyclinic of Bari - Department of Biomedical Sciences and Human Oncolog - University of Bari - Piazza Giulio Cesare 11 - 70124 Bari - Italy
Abstract :
Background: Recent studies have shown that cytokines have an important role in the
pathogenesis of inflammatory diseases and can be used as prognostic markers.
Objective: To evaluate the IL-6/IL-10 ratio in patients with Inherited Epidermolysis
Bullosa (EB) as a prognostic marker. Methods: Serum levels of IL-6 and IL-10 were
measured in 13 patients with recessive dystrophic EB (RDEB) as well as 10 with EB
Simplex (EBS), and in 18 healthy subjects. Receiver Operating Characteristics (ROC)
analyses were used to assess the diagnostic accuracy of the IL-6/IL-10 ratio for
detecting severe form of EB. Results: The IL-6/IL-10 ratio was statistically higher in
RDEB patients than in EBS patients and healthy subjects. The IL-6/IL-10 ratio
significantly correlated with BEBS score. Conclusion: Our findings suggest that IL-
6/IL-10 ratio >5.6 has a good diagnostic accuracy to identify patients with the highest
severity of disease.
Keywords :
Anti-Skin Autoantibodies , Birmingham Epidermolysis Bullosa Severity Score , Cytokines , IL-6/IL-10 Ratio , Inherited Epidermolysis Bullosa
Journal title :
Astroparticle Physics
