Author/Authors :
Mosannen Mozafari, Pegah Oral and Maxillofacial Diseases Research Center & Department of Oral Medicine - School of Dentistry- Mashhad University of Medical Sciences, Mashhad , Amirchaghmaghi, Maryam Oral and Maxillofacial Diseases Research Center & Department of Oral Medicine - School of Dentistry- Mashhad University of Medical Sciences, Mashhad , Delavarian, Zahra Oral and Maxillofacial Diseases Research Center & Department of Oral Medicine - School of Dentistry- Mashhad University of Medical Sciences, Mashhad , Iranshahi, Mehrdad Biotechnology Research Center & School of Pharmac - Mashhad University of Medical Sciences, Mashhad , Shakeri, Mohammad Taghi Department of Biostatistics & Epidemiology - School of Health - Mashhad University of Medical Science, Mashhad , Mohammadpour, Amir Hushang School of Pharmacy & Pharmaceutical Research Center - Mashhad University of Medical Sciences, Mashhad , Farazi, Fatemeh Department of Oral Medicine - School of Dentistry - North Khorasan University of Medical Sciences, Bojnurd , Iranshahy, Milad Department of Pharmacognosy - School of Pharmacy - Mashhad University of Medical Sciences, Mashhad
Abstract :
Background and aims. Standard treatment of oral lichen planus (OLP) includes topical or systemic corticosteroids that have many adverse effects. A trend toward alternative natural or herbal drugs has attended recently. This study was con-ducted to evaluate the effect of quercetin in treatment of erosive-atrophic OLP.
Materials and methods. Thirty patients participated in this randomized clinical trial from April 2010 to June 2010 (Trial
Registration Number: NCT01375101).Patients were randomly allocated in two groups. Both groups received the standard
treatment (dexamethasone mouthwash and nystatin suspension).Experimental group received oral 250 mg quercetin hydrate
capsules (bid) and the control group received placebo capsules. The pain and severity of the lesions were recorded at the
initial visit and the follow-ups. All recorded data were analyzed with chi-square, Mann-Whitney, t-test, Wilcoxon and
Friedman tests using SPSS 11.5.
Results. There were no significant differences between the two groups in severity of the lesions and pain in the follow-ups.According to the Friedman test, there was a significant reduction in pain (p=0.01) and severity indices (p=0.00) in the case group. These differences were not observed in the control group.(P=0.26,SI; and p = 0.86, PI). No adverse effect of quercetin was reported.
Conclusion. According to the results, no significant therapeutic effect can be considered for quercetin in treatment of OLP.
Keywords :
oral , quercetin , lichen Planus , Clinical trial
