Author/Authors :
İnal, Salih Department of Internal Medicine - Suleyman Demirel University Faculty of Medicine - Isparta, Turkey , Altuntaş, Atila Department of Internal Medicine - Suleyman Demirel University Faculty of Medicine - Isparta, Turkey , Kidir, Veysel Department of Internal Medicine - Suleyman Demirel University Faculty of Medicine - Isparta, Turkey , Özorak, Alper Department of Internal Medicine - Suleyman Demirel University Faculty of Medicine - Isparta, Turkey , Sezer, Mehmet Tugrul Department of Internal Medicine - Suleyman Demirel University Faculty of Medicine - Isparta, Turkey , İlgin, Yusuf Department of Internal Medicine - Suleyman Demirel University Faculty of Medicine - Isparta, Turkey
Abstract :
Background: In obstructive uropathy, despite a severe increase in the serum creatinine (Cr) levels, only a mild cystatin C (CysC)
increase was previously reported. Therefore, we aimed to determine the availability of serum Cr/CysC ratio in predicting postrenal
acute kidney injury (AKI). Materials and Methods: This was a cross-sectional study involving 61-adult patients with heterogeneous
AKI cases. Patients with bilateral pelvicalyceal dilatation in renal sonography were considered as postrenal AKI group (n = 15) and
others were intrinsic AKI group (n = 46). Venous blood sampling for blood urea nitrogen, Cr and CysC measurements were performed
on admission. Results: The mean age of study population was 66.3 ± 15.5 years; 38 (62%) of which were male. Two groups were similar
regarding age, gender, and comorbidities. Cr/CysC ratio was significantly higher in postrenal AKI group (6.9 ± 3.1 vs. 4.4 ± 2.1, P =
0.007). Conclusion: We suggest that serum Cr/CysC ratio seems to be a useful diagnostic tool for detection of postrenal AKI cases,
especially for the cases without definite hydronephrosis.
Keywords :
bstructive uropathy , postrenal acute kidney injury , creatinine/cystatin C ratio , cystatin C , Acute kidney injury
