Title of article :
Serum levels of glucagon-like peptide (GLP)-1 and GLP-2 in patients with Hashimoto’s thyroiditis
Author/Authors :
Jin, Yue Departments of Clinical Laboratory and Endocrinology and Metabolism - Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital - Huai’an - Jiangsu - 223 002, China , Liu, Hong Departments of Clinical Laboratory and Endocrinology and Metabolism - Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital - Huai’an - Jiangsu - 223 002, China , Ma, Shao-Gang Departments of Clinical Laboratory and Endocrinology and Metabolism - Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital - Huai’an - Jiangsu - 223 002, China , Cheng, Jian-Ping Departments of Clinical Laboratory and Endocrinology and Metabolism - Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital - Huai’an - Jiangsu - 223 002, China , Zhang, Kai Departments of Clinical Laboratory and Endocrinology and Metabolism - Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital - Huai’an - Jiangsu - 223 002, China
Abstract :
Background: The influence of Hashimoto’s thyroiditis (HT) with subclinical hypothyroidism or euthyroid status on the alteration
of glucagon-like peptide (GLP)-1 and GLP-2 levels remains uncertain. Materials and Methods: Twenty-four untreated HT patients
with subclinical hypothyroidism, 24 euthyroid HT patients, and 24 age- and gender-matched controls were enrolled in the study. The
levels of GLP-1, GLP-2, glucose, glycated albumin, insulin, thyroid hormone, and thyroid autoantibodies were measured and evaluated.
Results: The levels of GLP-1, blood glucose, and triglyceride were higher in HT patients with subclinical hypothyroidism than in
controls (all P < 0.05, respectively). However, the above variables, including GLP-2, were similar in euthyroid patients and controls.
Neither GLP-1 nor GLP-2 was correlated with thyroid hormone, thyroid autoantibodies or metabolic parameters. Conclusion: The
serum levels of GLP-1, not GLP-2, were increased in patients with subclinical hypothyroidism. Our data suggest that subclinical
hypothyroidism affects circulating GLP-1 levels.
Keywords :
subclinical hypothyroidism , Hashimoto’s thyroiditis , Glucagon-like peptide
Journal title :
Astroparticle Physics
