Author/Authors :
Wang, Dong Departments of Clinical Laboratory - The First Affi liated Hospital - The Hospital of Stomatology - Sun Yat-sen University - Guangzhou, China , Yang, Jing Departments of Clinical Laboratory - The First Affi liated Hospital - The Hospital of Stomatology - Sun Yat-sen University - Guangzhou, China , Zhang, Jianqing Departments of Clinical Laboratory - The First Affi liated Hospital - The Hospital of Stomatology - Sun Yat-sen University - Guangzhou, China , Zhang,Shihong Departments of Clinical Laboratory - The First Affi liated Hospital - The Hospital of Stomatology - Sun Yat-sen University - Guangzhou, China , Wang, bo Departments of Clinical Laboratory - The First Affi liated Hospital - The Hospital of Stomatology - Sun Yat-sen University - Guangzhou, China , Wang, Ruizhi Departments of Clinical Laboratory - The First Affi liated Hospital - The Hospital of Stomatology - Sun Yat-sen University - Guangzhou, China , Liu, Min Departments of Clinical Laboratory - The First Affi liated Hospital - The Hospital of Stomatology - Sun Yat-sen University - Guangzhou, China
Abstract :
Background: To investigate the association between the red cell distribution width (RDW) and mortality in patients with acute
pancreatitis (AP), and to assess the ability of RDW to predict mortality in AP patients. Materials and Methods: Th is retrospective
cohort study included 120 patients (50 males and 70 females) with AP who were admitted to the First Affi liated Hospital of Zhongshan
Medical University from January 2011 to October 2013. Demographic data and laboratory measures including RDW were obtained
from medical records of each patient. A receiver operating characteristic (ROC) curve analysis was used to assess RDW values to
predict the death of AP patients. Results: Th e serum concentration levels of total Ca2+ (P = 0.007) and albumin (P < 0.001), and
the white blood cell counts (P = 0.005) were signifi cantly lower, and the mortality rate (P < 0.001) and body mass index (P < 0.001)
were signifi cantly higher (P = <0.001, <0.001) in patients with RDW values of >13.4% than in patients with RDW values of ≤13.4%.
RDW values were negatively correlated with the serum concentration levels of albumin (r = −0.212, P = 0.012) and total Ca2+ (r =
−0.206, P = 0.033), and were positively correlated with the patient’s age (r = 0.201, P = 0.035). ROC analysis showed that the AUC
for the RDW value was 0.894 (P < 0.001, 95% confi dence interval = 0.823-0.966), and the optimal cut-off value to predict death was
14.35 (sensitivity = 88.2%, specifi city = 91.8%). Conclusion: Red cell distribution width is a potentially new and sensitive predictor
of mortality in patients with AP.
