Resveratrol and liver: A systematic review

Background: Recent studies demonstrated that resveratrol has many therapeutic eff ects on liver disorders. Resveratrol signifi cantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats. It provided liver protection against chemical, cholestatic, and alcohol injury. Resveratrol can improve glucose metabolism and lipid profi le and decrease liver fi brosis and steatosis. Furthermore, it was able to alter hepatic cell fatty acid composition. According to extension of liver disease around the world and necessity of fi nding new threat, this review critically examines the current preclinical in vitro and in vivo studies on the preventive and therapeutic eff ects of resveratrol in liver disorders. Materials and Methods: A search in PubMed, Google Scholar, and Scopus was undertaken to identify relevant literature using search terms, including “liver,” “hepatic,” and “Resveratrol.” Both in vivo and in vitro studies were included. No time limiting considered for this search. Results: A total of 76 articles were eligible for this review. In these articles, resveratrol shows antioxidative properties in diff erent models of hepatitis resulting in reducing of hepatic fi brosis. Conclusion: Resveratrol could reduce hepatic steatosis through modulating the insulin resistance and lipid profi le in animals. Th ese high quality preclinical studies propose the potential therapeutic implication of resveratrol in liver disorders especially those with hepatic steatosis. Resveratrol can play a pivotal role in prevention and treatment of liver disorders by reducing hepatic fi brosis.