Author/Authors :
Cheng, Zeneng Institute of Drug Metabolism and Pharmacokinetics - School of Pharmaceutical Sciences - Central South University, China , Ji, Shan Institute of Drug Metabolism and Pharmacokinetics - School of Pharmaceutical Sciences - Central South University, China , Wang, lei Institute of Drug Metabolism and Pharmacokinetics - School of Pharmaceutical Sciences - Central South University, China
Abstract :
Background: Th e eff ects of the vascular endothelial growth factor (VEGF) gene −2578C/A polymorphism on colorectal cancer (CRC) risk
have been investigated in some studies; however, the results of these studies were confl icting and ambiguous. Th erefore,we aimed to do a
meta-analysis to investigate the association of VEGF −2578C/A polymorphisms with CRC risk from all eligible case-control studies published
to date. Materials and Methods: An electronic search of the PubMed, Embase and Medline was performed. Retrieve terms were utilized
as following: (“VEGF a” [MeSH Terms]) and (“polymorphism, genetic” [MeSH Terms]) and (“colorectal neoplasms” [MeSH Terms]). Th e
association between VEGF −2578C/A polymorphisms with CRC risk was calculated with odds ratios (ORs) and their corresponding 95% of
confi dence intervals (CIs), and stratifi ed analysis was also conducted with respect to ethnicity. Results: A comprehensive meta-analysis of
eight studies, including 2312 cases and 2308 controls was performed in this work. Combined analysis revealed that a signifi cant association
between the VEGF −2578C/A polymorphism with CRC risk was identifi ed in three comparison models including C allele versus A allele
(OR = 0.85, 95% CI 0.75-0.97, P = 0.02), AA versus CA + CC (OR = 1.28, 95% CI 1.09-1.51, P = 0.003), and AA versus CC (OR = 0.77, 95%
CI 0.64-0.93, P = 0.006). Moreover, a similar result was obtained in the subgroup analysis that comparison models of C allele versus. A allele
(OR = 0.85, 95% CI 0.76-0.95, P = 0.004), AA versus CA + CC (OR = 1.31, 95% CI 1.09-1.57, P = 0.004), and AA versus CC (OR = 0.73,
95% CI 0.59-0.90, P = 0.004) was confi rmed to be associated with CRC risk in Caucasian. Conclusion: It has been proved that the C allele
versus A allele, AA versus CA + CC, and AA versus CC comparison models of VEGF −2578C/A polymorphism might be risk factors for
CRC, but further studies with larger sample sizes are required to make a better assessment of above association.
Keywords :
vascular endothelial growth factor , meta-analysis , Colorectal cancer , polymorphism
