Author/Authors :
Salehi, Mohammad Mahdi , Salehi, Maryam , Haghighat, Abbas , Salehi, Hassan Infectious Diseases and Tropical Medicine Research Center , Taleban, Roya , Salehi, Marzieh Student Research Committee - School of Medicine, Isfahan University of Medical Sciences , Kalbasi, Nader Department of Pathology - School of Dentistry - Islamic Azad University (Khorasgan Branch) , Moafi, Mohammad Acquired Immunodeficiency Research Centre - Isfahan University of Medical Sciences, Isfahan
Abstract :
Background: Hepatitis B virus (HBV) fails to produce appropriate immune responses in some healthy individuals; thus, different
strategies have been adopted to promote immune responses. The current study aimed at evaluating the efficacy of HBV vaccine
coadministered with tetanus-diphtheria (Td) vaccine compared with HBV vaccine in healthy individuals through measuring hepatitis
B surface antibody (HBsAb) levels. Materials and Methods: This was a randomized controlled clinical trial, which was implemented
in Isfahan, Isfahan Province (Iran) in 2013. One hundred and forty healthy individuals, whose HBsAb titers were less than 10 IU/L
were recruited. The subjects were randomly assigned to either in intervention or control trials. The control group received 40 μg
of recombinant HBV vaccines intramuscularly injected at 0, 1, and 6 months; however, the intervention group was simultaneously
vaccinated by Td with the first dose of HBV vaccine. HBV antibody levels (titer) were measured before the vaccination and 6 months
after the last vaccination. Results: Antibody titers of the subjects in the intervention and control groups increased from 5.07 ± 2.9
IU/L to 744.45 ± 353.07 IU/L and from 4.45 ± 3.4 IU/L to 589.94 ± 353 IU/L, respectively (both P < 0.001). Also, the mean difference
of antibody titer was significantly different between the two groups (P = 0.011). Conclusion: Td vaccination can be applied as a
feasible approach to promote efficient and persistent immunity in healthy individuals with insufficient HBsAb titers.
