Title of article
Protective effect of selenium against aluminium chloride induced cardiotoxicity in rats
Author/Authors
Zeghal, Najiba Animal Physiology Laboratory - Sciences Faculty of Sfax - University of Sfax - BP 1171 - 3000 Sfax, Tunisia , Ghorbel, Imen Animal Physiology Laboratory - Sciences Faculty of Sfax - University of Sfax - BP 1171 - 3000 Sfax, Tunisia , Elwej, Awatef Animal Physiology Laboratory - Sciences Faculty of Sfax - University of Sfax - BP 1171 - 3000 Sfax, Tunisia , Chaabane, Mariem Animal Physiology Laboratory - Sciences Faculty of Sfax - University of Sfax - BP 1171 - 3000 Sfax, Tunisia , Jamoussi, Kamel Biochemistry Laboratory - CHU Hedi Chaker - University of Sfax - 3029 Sfax, Tunisia
Pages
7
From page
19
To page
25
Abstract
Our study pertains to evaluate the protective effect of selenium (Se), used as a nutritional supplement, against aluminium chloride
induced cardiotoxicity in rats. Rats have received during 21 days either AlCl3 (400 ppm) via drinking water, AlCl3 associated
with Na2SeO3 (0.5 mg/kg of diet) or only Na2SeO3. Co-administration of Se to AlCl3 treated rats alleviated heart oxidative stress
objectified by a decrease of malondialdehyde, hydrogen peroxide and protein carbonyls levels. An improvement in antioxidant
redox status, enzymatic (catalase, superoxide dismutase and glutathione peroxidase) and non enzymatic (reduced glutathione, non
protein thiols and vitamin C) was also observed in Se treated rats. LDH and CK activities, TC, LDL-C levels, TC/HDL-C and
LDL-C/HDL-C ratios were increased, while HDL-C and TG decreased in rats treated with AlCl3. Cardiac biomarkers and lipid
profile were restored to near control values by the supplementation of Se. Our results revealed that Se, a trace element with
antioxidant properties, was effective in preventing heart damage induced by aluminium chloride.
Keywords
heart , selenium , oxidative stress , rats , Aluminium
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2430701
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