Author/Authors :
Vosough, Parvaneh Oncology Service - Mahak Hospital - The Society for Supporting the Children Suffering from Cancer, Tehran , Ghassemi, Fariba Assistant Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Chams, Hormoz Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Karkhaneh, Reza Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Sabour, Siamak Assistant Professor of Epidemiology - Epidemiology Service - Medicine Faculty - Shahid Beheshti University of Medical Sciences, Tehran , Farzbod, Farzad Fellowship in Vitreoretina - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Khodaparast, Mahdi Ophthalmologist - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran
Abstract :
Purpose: Retinoblastoma (RB) is a relatively common childhood tumor. In this report we discuss the
clinical characteristics, treatments and outcome of the treated RB patients from a referral center in
Iran in order to understand this medical problem in our society.
Methods: A retrospective study was carried out on RB cases treated in Farabi Eye Hospital since
1979 to 2007. The variables analyzed were age, sex, affected eyes, time of the diagnosis,
treatment modalities, pathological findings and the survival rate.
Results: We analyzed 557 cases with a mean age of 32.2 months [standard Deviation (SD)= 22].
There was a male predominance (60%). There were 380 unilateral cases (68.6%). Enucleation
was performed in 65.6% of the patients. Nearly 82% of the eyes were in group Va and Vb
Reese-Ellsworth or in a very advanced condition. Of the enucleated cases, 43.2% of the eyes have
had undifferentiated types of tumors. Disease free survival was 68.5% in this study (by a mean
follow-up of 61.9 months).
Conclusion: Considering the advanced stages of disease in the majority of patients at the time of
diagnosis, the enucleation ratio of our RB patients was higher than other countries.
