Author/Authors :
Zarei, Reza Associate Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Soleimani, Mohammad Associate Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Mohammadi, Masoud Associate Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Tabatabaei, Ali Associate Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Fakhraie, Ghasem Associate Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Eslami, Yadollah Associate Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Moghimi, Sasan Associate Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Daneshvar, Ramin Assistant Professor of Ophthalmology - Eye Research Center - Mashhad University of Medical Sciences, Mashhad , Razzaghi, Mohammad Assistant Professor of Ophthalmology - Labbafinejad Hospita - Shahid Beheshti University of Medical Sciences, Tehran , Amini, Heidar Professor of Ophthalmology - Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Amini, Nima Department of Health Sciences at California State University - Northridge, USA , Zarei, Hossein MSC Risk Management Brunel University - London, UK
Abstract :
Purpose: To compare retinal nerve fiber layer (RNFL) profile in subjects with myopia and
emmetropia using GDx variable corneal compensator (VCC)
Methods: Besides ophthalmologic standard examination (refraction, visual acuity and slit-lamp
examination, applanation tonometry, and funduscopy), perimetry and scanning laser polarimetry
(SLP) were performed. 171 healthy age-matched subjects with low to high myopia (90 subjects)
and emmetropia (81 subjects) underwent RNFL analysis by means of GDx VCC. The mean value
of each parameter was compared in myopic and emmetropic eyes.
Results: Mean myopia was 3.43±1.19 diopter (D) (range, -0.50 to -6.50). Except for ratio
parameters, RNFL parameters were significantly lower in myopic patients. TSNIT standard
deviation (p=0.026), nerve fiber indicator (NFI) (p=0.027), superior/nasal (p<0.0001), max
modulation (p=0.003), ellipse modulation (p=0.0244) and Symmetry (p=0.028) were higher in
myopic group. In both groups, all of RNFL measurements were within the normal range. There was
a gradual decrease in RNFL thickness associated with aging in myopic patients (simple regression
analysis, p<0.05). There was also a gradual decrease in temporal-superior-nasal-inferior thickness
(TSNIT) average and superior maximum with increasing degree of myopia (simple regression
analysis, p<0.05).
Conclusion: RNFL thicknesses gradually decreased with increasing age in myopic patients.
Patients with myopia had significantly lower RNFL thickness than normal subjects and, although
weakened by wide age range of myopic group, there was a linear negative correlation between
severity of myopia and RNFL thickness in myopic patients.
Keywords :
GDx , Scanning Laser Polarimetry , Retinal Nerve Fiber Layer , Emmetropia , Myopia
