Author/Authors :
Fotouhi, Akbar Department of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences, Tehran , Hashemi, Hassan Noor Ophthalmology Research Center - Noor Eye Hospital, Tehran , Ghafari, Elina Noor Ophthalmology Research Center - Noor Eye Hospital, Tehran , Khabazkhoob, Mehdi Noor Ophthalmology Research Center - Noor Eye Hospital, Tehran , Noori, Jila Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Taheri, Arash Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Eshghabadi, Arash Noor Ophthalmology Research Center - Noor Eye Hospital, Tehran , Khodabandeh, Alireza Noor Ophthalmology Research Center - Noor Eye Hospital, Tehran , Emamian, Mohammad Hassan Center for Health Related Social and Behavioral Sciences Research - Shahroud University of Medical Sciences, Shahroud , Shariati, Mohammad Department of Community Medicine - School of Medicine - Tehran University of Medical Sciences, Tehran
Abstract :
Purpose: To determine the prevalence and determinants of age-related macular degeneration
(AMD) in a 40-64 year old Iranian population
Methods: In a cross-sectional study, 6,311 people were randomly selected from Shahroud. For all
participants, visual acuity, refraction, slit-lamp examination and fundus photography were
conducted under pupil dilation.
Results: Results of this study are based on analysis of 4,387 high quality photographs. The
prevalence of AMD in this study was 4.7% (95% confidence interval (CI): 4.1-5.4). Multiple logistic
regression analysis revealed that only older age [odds ratio (OR)=1.07] and hyperopia (OR=1.12)
significantly correlated with AMD. Associations with biometric components and spherical equivalent
were studied in another model and older age (OR=1.08), male sex (OR=1.54), and ocular axial
length (OR=0.66) significantly correlated with AMD.
Conclusion: AMD prevalence in this population was lower compared to Western countries and
higher in comparison to East Asian countries. In agreement with other studies, age strongly
correlated with AMD. Regarding the correlation between AMD and ocular axial length; the
incidence is more likely to occur in people with short axial lengths.
