Granular Cell Tumor of Ocular Adnexa; Report of Three Cases and Review of Literature

Purpose: Granular cell tumors (GCT) are benign unusual neoplasms which have been proven to have a Schwann cell phenotype. They rarely occur in the eye region. Case reports: We report three cases of GCT in the ocular adnexa including palpebra, subconjuctiva and orbit which rarely occur. Patients are, a young girl with the lesion in orbit and presentation of proptosis, a middle aged man with the lesion in nasal limbus and erythema presentation and as well as an old age woman with the lesion in eyelid and protrusion. Morphologic examination of above cases show similar histology composed of polygonal cells which contained PAS positive eosinophilic granules. The S-100 protein and CD68 tests were positive in immunohistochemical stainngs. Conclusion: GCT occurs in different sites and ages, so they should be considered in the differential diagnosis of eye tumors in children and adults.