Endometrial Stromal Sarcoma Presented with Galactorrhea

Sarcomas are rare forms of endometrial (uterine) cancer. We report here a 52 years old woman who was hospitalized due to abnormal uterine bleeding (menorrhagia). The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and para-iliac lymphadenectomy. The pathological result was endometrial stromal sarcoma/low grade. Meanwhile, she had an ESR of 80 mm/h. After 4 years, the patient referred with dyspnea and galactorrhea. Her serum prolactin level was more than 100 ng/ml. The lung CT-scan revealed metastatic lesions. Brain MRI with hypophysis view was normal. Thus chemotherapy with CYADIC regimen was begun for her and her ESR reached 13. Also, a decline in prolactin level occurred. After 2 years, she was hospitalized for abdominal pain and the assessments revealed progressive metastasis of the abdomen and whole body scan demonstrated the metastatic bone disease. Also, prolactin level highly increased (11102 mIu/Lit). The MRI of the brain was normal again. Serum macroprolactin was measured, revealing a negative result. The ESR reached 80 mm/h.