Possible Role of Descemet–Stroma Interface for Descemet’s Membrane Detachment after Penetrating Keratoplasty

Purpose: To report two cases of spontaneous Descemet’s membrane detachment (DMD) and dehiscence following penetrating keratoplasty (PK). Case Reports: Spontaneous DMD or Descemet’s membrane (DM) dehiscence following PK is a rare occurrence. Here, we describe two cases of such an occurrence following PK arising from the graft–host interface. A possible causative relation between DMD/dehiscence and DM–stromal interface attachment is suggested. Conclusion: DMD and dehiscence after PK can be explained by the peripheral thinning of DM and possible changes to the recently characterized anchoring zone of interwoven collagen fibers and proteoglycans at the Descemet–stroma interface.