Title of article :
Interleukin-4 and interferon- γ levels in Epstein-Barr virus-associated infectious mononucleosis and nasopharyngeal carcinoma
Author/Authors :
Budiani, Dyah R Department of Pathology - School of Medicine - Sebelas Maret University - Surakarta, Indonesia , Haryana, Sofia M Department of Histology and Cell Biology - School of Medicine - Gadjah Mada University - Yogyakarta, Indonesia , Sosroseno, Wihaskoro School of Dentistry - AIMST University - Semeling, Bedong - Kedah, Malaysia
Abstract :
BACKGROUND: Cytokines have been suggested to participate in the pathogenesis of infectious mononucleosis (IM) and
nasopharyngeal carcinoma (NPC).
METHODS: Serum levels and gene expression of interleukin-4 (IL-4) and interferon-γ (IFN-γ) were assessed by immunologic
and PCR assays, respectively in patients with Epstein-Barr virus (EBV)-associated IM and NPC and EBV negative
controls.
RESULTS: The serum levels of IFN- γ were elevated, but those of IL-4 were decreased in IM and NPC patients as compared
with those of the control group (p < 0.05).
CONCLUSIONS: These results suggest that serum levels of IFN-γ may be predominant over those of IL-4 during the
course of IM and NPC.
Keywords :
Interferon-Gamma , Interleukin-4 , Infectious Mononucleosis , Nasopharyngeal Neoplasms
Journal title :
Astroparticle Physics
