Title of article :
The effect of vitamin A and vitamin C on postoperative adhesion formation: A rat model study
Author/Authors :
Keleidari, Behrouz Departments of Surgery - Faculty Member of General Surgery - Isfahan University of Medical Sciences, Isfahan , Mahmoudieh, Mohsen Departments of Surgery - Faculty Member of General Surgery - Isfahan University of Medical Sciences, Isfahan , Bahrami, Faranak Departments of Surgery - Faculty Member of General Surgery - Isfahan University of Medical Sciences, Isfahan , Mortazavi, Pejman Departments of Pathobiology - Veterinary, Sciences, Science and Research Branch - Faculty Member of Islamic Azad University, Tehran , Sari Aslani, Reza Departments of Surgery - Resident of General Surgery - Isfahan University of Medical Sciences, Isfahan , Toliyat, Alireza Departments of Surgery - Resident of General Surgery - Isfahan University of Medical Sciences, Isfahan
Abstract :
Background: Th e aim of this study is to investigate the eff ect of vitamin A and C, as the agents that improve wound healing, on the
adhesion formation process. Materials and Methods: Sixty male Wistar rats were used. Th ey underwent midline laparotomy, for repair
of a peritoneal injury, and were then assigned to four groups. Group 1 (Vitamin A) received 2000 units/kg intramuscular injection
of vitamin A daily, post surgery, for two weeks; Group 2 (Vitamin C) received 100 mg/kg oral vitamin C daily, after laparotomy, for
two weeks; Group 3 (vitamins A and C) received 2000 units/kg intramuscular injection of vitamin A and 100 mg/kg oral vitamin C
daily, after laparotomy, for two weeks, and Group four (Sham) rats did not receive any drugs. Th e adhesion, infl ammation, fi brosis
scores, and wound integrity were evaluated after two weeks. Results: Rats in the vitamin C group had the lowest mean adhesion
formation score (1 ± 0.27) and the values of p were < 0.0001 for the vitamin A group and vitamin A and C groups and 0.003 for the
sham group. Vitamin C also had the lowest fi brosis score (0.50 ± 0.17) among the study groups and the values of p were < 0.0001
for the vitamin A group and vitamin A and C groups and 0.002 for the sham group. Th e mean infl ammation score did not diff er
signifi cantly among the study groups. Th e wound disruption strength was the highest in the vitamin C group and the diff erence
was statistically signifi cant in the sham group (1188.69 ± 281.92 vs. 893.04 ± 187.46, p : 0.003). Conclusion: Administration of oral
vitamin C reduces adhesion formation and improves wound healing
Keywords :
Adhesion formation , vitamin A , vitamin C
Journal title :
Astroparticle Physics
