Title of article :
Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women
Author/Authors :
Allameh, Zahra Isfahan University of Medical Sciences, Isfahan , Ghasemi Tehrani, Hatav Isfahan University of Medical Sciences, Isfahan , Hashemi, Mohammad Isfahan University of Medical Sciences, Isfahan , Basirat Nia, Reza Isfahan University of Medical Sciences, Isfahan , Hoseini, Forough Isfahan University of Medical Sciences, Isfahan
Abstract :
Background: To assess the endothelial function via noninvasive method, in pregnant women with preeclampsia compared
to to normotensive pregnant women. Materials and Methods: Brachial artery diameter was measured via ultrasound, in
28 women with preeclampcia in case group and normotensive pregnant women in control group, at rest, after inflation of
sphygmomanometer cuff up to 250-300 mmHg, immediately after deflation of the cuff, 60-90 minutes later and 5 min after
administration of sublingual trinitroglycerin (TNG). Results of these measurements as well as demographic characteristics
of participants in both groups were recorded in special forms. Data were analyzed via Statistical Package for Social Sciences
(SPSS) version 16, using t-test and repeated measures analysis of variance (ANOVA). P-value < 0.05 was considered statistically
significant. The results were presented as mean ± standard deviation (SD). Results: The mean of brachial artery diameter at
rest in the case and control groups was 4.49 ± 0.39 and 4.08 ± 0.38 mm, respectively (P = 0.1). Also the results showed that
the brachial artery diameter, immediately after deflation of the cuff, was 4.84 ± 0.4 and 4.37 ± 0.30 mm in the case and control
groups (P < 0.001), respectively. The mean brachial artery diameter, 60-90 s after deflation of the cuff, was 4.82 ± 0.41 and 4.42
± 0.38 mm in the case and control groups (P < 0.00), respectively. The brachial artery diameter, 5 min after sublingual NO
administration, was 4.95 ± 0.6 and 4.40 ± 0.45 mm in case and control groups (P < 0.001), respectively. Applying of repeated
measures ANOVA showed that the mean difference between case and control groups was statistically significant (P < 0.001).
Conclusion: Current study concluded that there is no difference in endothelium-dependent vasodilation between women with
preeclampsia and pregnant women with normal blood pressure.
Keywords :
Brachial artery diameter , endothelium-dependent vasodilation , Endothelium-dependent vasodilation-Preeclampsia- Nitric oxide (NO) , normotensive , NO , preeclampsia
Journal title :
Astroparticle Physics
