Title of article :
Lipid regulatory genes polymorphism in children with and without obesity and cardiometabolic risk factors: The CASPIAN‑III study
Author/Authors :
Hovsepian, Silva Department of Pediatrics - Child Growth and Development Research Center - Research Institute for Primordial Prevention of Non-communicable Disease - Emam Hossein Children’s Hospital , Haghjooy Javanmard, Shaghayegh , Mansourian, Marjan Department of Biostatistics and Epidemiology - School of Health - Isfahan University of Medical Sciences, Isfahan , Hashemipour, Mahin Department of Pediatrics - Emam Hossein Children’s Hospital - Isfahan University of Medical Sciences, Isfahan , Tajadini, Mohamadhasan , Kelishadi, Roya Department of Pediatrics - Child Growth and Development Research Center - Research Institute for Primordial Prevention of Non-communicable Disease - Isfahan University of Medical Sciences, Isfahan
Abstract :
Background: Genetically, predisposed children are considered as at‑risk individuals for cardiovascular disease. In this study, we
aimed to compare the frequency of four‑lipid regulatory polymorphism in obese and normal‑weight children with and without
cardiometabolic risk factors. Materials and Methods: In this nested case–control study, 600 samples of four groups of participants
consisted of those with normal weight with and without cardiometabolic risk factors and obese with and without cardiometabolic
risk factors. Allelic and genotypic frequencies of GCKR (rs780094), GCKR (rs1260333), MLXIPL (rs3812316), and FADS (rs174547)
polymorphisms were compared in the four studied groups. Results: Data of 528 samples were complete and included in this study.
The mean (standard deviation) age of participants was 15.01 (2.21) years. Frequency of tt allele (minor allele) of GCKR (rs1260333)
polymorphism was significantly lower in normal weight metabolically healthy participants than metabolically unhealthy
normal weight (MUHNW) and obese children with and without cardiometabolic risk factor (P = 0.01). Frequency of ga allele of
GCKR (rs780094) polymorphism was significantly higher in normal weight children with cardiometabolic risk factor than in their
obese counterparts with cardiometabolic risk factor (P = 0.04). Frequency of cg and gg alleles (minor type) of MLXIPL (rs3812316)
polymorphism in normal weight metabolically healthy participants was significantly higher than MUHNW (P = 0.04) and metabolically
healthy obese children (P = 0.04). Conclusion: The findings of our study indicated that the minor allele of GCKR (rs1260333)
single nucleotide polymorphisms (SNPs) could have pathogenic effect for obesity and cardiometabolic risk factors. Ga allele of
GCKR (rs780094) SNPs had a protective effect on obesity. Minor alleles of MLXIPL (rs3812316) could have a protective effect for
obesity and cardiometabolic risk factors.
Keywords :
Children , fatty acid desaturases , glucokinase regulatory protein , metabolic syndrome , MLXIPL protein , obesity , polymorphism
Journal title :
Astroparticle Physics
