What is the role of erythropoietin prolotherapy on pain relief of knee osteoarthritis?

Knee osteoarthritis is one of the prevailing chronic joint diseases in the world. Doctors have always searched for the new, effective treatment methods with the least side effects. Intra‑articular prolotherapy is one of the recent treatment methods to address chronic and severe pain. Using growth‑stimulating substances, this method activates an inflammatory cascade and releases inflammatory factors resulting in cellular growth and accelerated cartilage building.[1,2] Erythropoietin is a blood cell proliferation and growth‑stimulant substance recently used in damaged ligaments and muscles prolotherapy