Author/Authors :
Kroll, Pawel Department of Pediatric Surgery - Traumatology and Urology - Poznan University of Medical Sciences - Szpitalna - Poznan, Poland , Jankowski, Andrzej Department of Pediatric Surgery - Traumatology and Urology - Poznan University of Medical Sciences - Szpitalna - Poznan, Poland , Soltysiak, Jolanta Department of Pediatric Nephrology - Poznan University of Medical Sciences - Szpitalna, Poznan, Poland , Murias, Marek Department of Toxycology - Poznan University of Medical Sciences - Szpitalna - Poznan, Poland , Skrzypczak, Magdalena Department of Human Biological Development - Institute of Anthropology - Szpitalna - Poznan, Poland , Zachwieja, Jacek Department of Pediatric Nephrology - Poznan University of Medical Sciences - Szpitalna, Poznan, Poland
Abstract :
Background: Botulinum-A toxin (BTX) administration appears to be useful in patients with high
pressure neurogenic bladder.
Objectives: The aim of this study was to evaluate the usefulness of cystoscopic injections of BTX
in the detrusor wall in the treatment of children with overactive neurogenic bladder dysfunctions.
Patients and Methods: The prospective, non-placebo controlled study was conducted with the
approval of Local Ethics Committee. The study group consisted of 31 girls and 34 boys with
neurogenic bladder overactivity, aged from 1 to 14 and treated with Botulinum-A toxin (Dysport,
Ipsen).
Results: Both values of volumes of the catheterized urine and bladder volumes in urodynamic
studies increased significantly after the therapy and it proved that the younger patient the
more effective the percentage of volumes growth.
Conclusion: The results showed that endoscopic administration of BTX improved functional
parameters of urinary bladder in cases of children with neurogenic bladder and the method
might represent an alternative approach to operative reduction of intravesical pressures.
