Author/Authors :
Uz, Ebru Department of Nephrology - Fatih University Medical School - Ankara, Turkey , Bayram, Yeter Department of Internal Medicine - Fatih University Medical School - Ankara, Turkey , Haltas, Hacer Department of Pathology - Fatih University Medical School - Ankara, Turkey , Bavbek, Nuket Department of Nephrology - Fatih University Medical School - Ankara, Turkey , Kanbay, Mehmet Department of Nephrology - Fatih University Medical School - Ankara, Turkey , Guz, Galip Department of Nephrology - Gazi University Medical School - Ankara, Turkey , Akçay, Ali Department of Nephrology - Fatih University Medical School - Ankara, Turkey
Abstract :
Karyomegalic tubulointerstitial nephritis is a rare disease of uncertain etiology with
typical clinical features of slowly progressive renal failure in the third decade of life.
Histological findings characterize striking enlarged and hyperchromic nuclei in numerous
tubular epithelial cells throughout the nephron accompanied by interstitial
fibrosis around atrophic tubules. Herein, we report a case of 30 year-old patient who
presented with asymptomatic progressive renal dysfunction in 2009. Renal biopsy
revealed chronic tubulointerstitial nephritis and an unusually marked karyomegaly
particularly of the tubular epithelium.
