L-Carnitine supplementation in uremic patients

We read with interest the paper of Debska-Slizien A et al. (1), recently published in Nephro-Urology Monthly which focused on the impact of L-Carnitine on management of anemia among dialysis patients. We know that plasma free carnitine concentration in hemodialysis patients is reduced (19.2-32.4 umol/L) and significantly lower than in healthy controls (40-50 umol/L) or in chronic kidney disease patients. Several factors contribute to this abnormal profile (2) containing of reduction in endogenous carnitine synthesis and limitation in dietary intake and hemodialysis removal. We are agree with Debska-Slizien A et al