Author/Authors :
Uz, Ebru Department of Internal Medicine - Division of Nephrology - Faculty of Medicine - Fatih University - Ankara, Turkey , Uz, Burak Department of Internal Medicine - Faculty of Medicine - Fatih University - Ankara, Turkey , Kaya, Arif Department of Internal Medicine - Faculty of Medicine - Fatih University - Ankara, Turkey , Akdeniz, Derya Department of Internal Medicine - Faculty of Medicine - Fatih University - Ankara, Turkey , Ruzgaresen, Nuket Bavbek Department of Internal Medicine - Division of Nephrology - Faculty of Medicine - Fatih University - Ankara, Turkey , Uz, Efkan Faculty of Medicine - Suleyman Demirel University - Ankara, Turkey , Turgut, Faruk Hilmi Department of Internal Medicine - Division of Nephrology - Faculty of Medicine - Fatih University - Ankara, Turkey , Bayrak, Reyhan Department of Pathology - Faculty of Medicine - Fatih University - Ankara, Turkey , Akcay, Ali Department of Internal Medicine - Division of Nephrology - Faculty of Medicine - Fatih University - Ankara, Turkey
Abstract :
Background: Cyclosporine (CsA) is a clinically used immunosuppressive agent; but nephrotoxicity
is a serious side effect of this drug. Some antioxidants may be used to
diminish oxidative stress related to cyclosporine.
Objectives: The aim of this study was to determine the protective effect of erdosteine
on CsA induced chronic nephrotoxicity.
Materials and Methods: We assessed oxidative stress enzymes (SOD, CAT, GSHPx, MDA,
NO and PC levels) and light microscopic changes before and after erdosteine treatment
in damaged kidney. The rats were assigned randomly to one to four groups.
These were: control group (n = 8), CsA group (15 mg/kg day, n = 8), erdosteine treated
group (10 mg/kg day orally, n = 8) and CsA + erdosteine group (n = 8). CsA nephrotoxicity
was induced by administrating oral dose of 15 mg/kg CsA daily for 21 days.
Results: We observed that the activities of glutathione peroxidase (GSHPx) were higher
and MDA, NO activities were lower in CsA plus erdosteine group than in CsA group.
Histological parameters significantly improved after erdosteine treatment.
Conclusions: Erdosteine does seem to have a protective effect on CsA nephrotoxicity by
reducing oxidative stress.
