Insights into the Possible Mechanism of Cyclosporine-Induced Chronic Nephrotoxicity; Arteriolopathy

I read with great interest the recent contribution by Uz et al. (1) that demonstrated the protective effects of erdosteine on cyclosporine (CsA)-induced chronic nephrotoxicity in rats. The authors however, did not suggest the possible mechanism of nephrotoxicity or the recent reports concerning the action of antioxidants on nephrotoxicity. I would like to add some considerations on the noteworthy results using antioxidants based on the mechanism of CsA-induced chronic nephropathy.