Monitoring of Cyclosporine A Blood levels in Clinical Settings

I would like to comment on the paper by Beiraghdar et al. (1). C2 is regarded as a better indicator of cyclosporine A (CsA) exposure compared to C0 (2), this is also the case in pediatric patients (3). however, in clinical settings, C0 monitoring seems to be more reliable. It is connected to the fact that, CsA blood concentration is quite stable for between 10 and 12 hours after administration, and the collection of blood during that time allows valuable clinical results to be obtained. on the other hand, the peak concentration is obtained 2 hours after administration only in a limited group of patients, so called “good absorbers.” In delayed absorbers, C2 is not fully reliable(4).