Ultrapure Dialysis Fluid: A New Standard for Contemporary hemodialysis

The concept of renal replacement therapy (RRT) has evolved considerably over the last 2 decades. Dialysis, a key component of RRT intended to clear uremic toxins and periodically restore the internal milieu composition, has benefited from considerable advances in dialysis technology (bicarbonate-buffered dialysis fluid, ultrafiltration- controlled systems, profiling systems, blood volume and temperature control, direct quantification, and high-flux dialyzers) and innovative adjunctive drug therapies designed to correct anemia (erythropoietinstimulating agents (ESA), IV iron, etc.), metabolic bone disease (vitamin D and analogs, calcimimetics, etc.), and associated metabolic disorders (lipid-lowering agents, antioxidants, etc.) (1).