Title of article :
Strategies to Extend Warm Ischemia Time during Laparoscopic Partial Nephrectomy- Part II
Author/Authors :
Dorai, Thambi Department of Urology - Saint Vincent Catholic Medical Centers - New York, USA , Michels, Catherine Department of Urology - New York Medical College - Valhalla, USA , Goldfarb, David S New York Harbor Health Care System and New York University School of Medicine - New York, USA , Grasso, Michael Department of Urology - Saint Vincent Catholic Medical Centers - New York, USA
Abstract :
Background and Aims: In this part of the review, particular attention is drawn towards the mechanisms
by which one can pre-condition the kidneys pre-operatively by using several strategies that
are nutritional, biochemical, pharmacological and environmental in nature. In addition, ideas and
hypotheses are put forward that are relevant to modulating the anoxic and autophagic response
to ischemic damage during laparoscopic partial nephrectomy, particularly with respect to reducing
the endoplasmic reticulum stress. Finally, the current trends in research involving the role of stem
cells, renal hibernation and the role of the innate immune response are highlighted with the aim
of exploiting these mechanisms to achieve reduced kidney damage during ischemia. Finally, the
common thread behind all these approaches, namely empowering the renal mitochondria during
ischemia is emphasized.
Keywords :
Laparoscopic Partial Nephrectomy , Ischemia , Hypoxia , Anoxia , Mitochondrial Dysfunction , Reactive Oxygen Species
Journal title :
Astroparticle Physics
