Author/Authors :
Bastani, Bahar Saint Louis University, USA , Heshmatzade Behzadi, Ashkan Department Research Center - Iran University of Medical Sciences and Health Services, Tehran , Abbasi, Mohammad Amin Department Research Center - Iran University of Medical Sciences and Health Services, Tehran , Hassanloo, Jaleh Department Research Center - Iran University of Medical Sciences and Health Services, Tehran , Ansari, Kayvan Department Research Center - Iran University of Medical Sciences and Health Services, Tehran , Sedaghati, Mahsa Department Research Center - Iran University of Medical Sciences and Health Services, Tehran , Honarbakhsh, Yasamin Department Research Center - Iran University of Medical Sciences and Health Services, Tehran , Akasheh, Amir Poya Department Research Center - Iran University of Medical Sciences and Health Services, Tehran , Alghasi, Mohsen Baqiyatallah University of Medical Sciences , Rafiezadeh, Parviz Department of Nephrology and Urology - Kerman University of Medical Sciences, Kerman , Masouminia, Maryam Department Research Center - Iran University of Medical Sciences and Health Services, Tehran , Kamali, Koosha Department of Urology - Hasheminejad Hospital - Iran University of Medical Sciences, Tehran
Abstract :
Background and Aims: There is controversy on change of Prostate specific antigen (PSA) levels after some
urological procedures such as cystoscopy. In this study, we evaluated the effect of cystoscopy on PSA levels
in patients with urologic diseases.
Methods: In a before-after study, 190 patients with urologic diseases such as relapsing urinary tract infection
(UTI), urinary incontinency, hematuria, transitional cell carcinoma (TCC) follow up, DJ catheter removal and
urinary retention were investigated. PSA levels were measured before and after cystoscopy.
Results: Mean age of patients was 63±13 years. Mean duration of procedure was 2.5±1.2 minutes. Total PSA
level increased in all groups after cystoscopy. More changes were found in patients with urinary retention
(P<0.01). There was a relation between patients’ ages and primary and secondary PSA levels (P=0.0001).
Moreover there was a statistically significant direct relation between the PSA levels and the duration of
procedures in different groups of patients (P=0.001).
Conclusions: Total PSA increases after cystoscopy and the level of PSA is higher in patients with urinary
retention and change in level of PSA was higher in these patients. The results can have implications for the
screening for prostate cancer patients.
