Title of article :
Direct Renin Inhibitor: Aliskiren in Chronic Kidney Disease
Author/Authors :
Morishita, Yoshiyuki Department of Medicine - Jichi Medical University - Tochigi, Japan , Kusano, Eiji Department of Medicine - Jichi Medical University - Tochigi, Japan
Abstract :
The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of chronic kidney disease
(CKD) progression and its increased complications such as hypertension (HT) and cardiovascular diseases (CVD). Previous
studies suggested that aliskiren a direct renin inhibitor, blocks RAAS and may be effective for the management of
CKD and its complications. This review focuses on the effects of aliskiren on CKD.
Keywords :
Kidney Failure , Chronic , Renin-Angiotensin System , Aliskiren , Blood Pressure , Cardiovascular Diseases
Journal title :
Astroparticle Physics
