Author/Authors :
Sharifi Mood, Batool Department of Infectious Diseases - Zahedan University of Medical Sciences, Zahedan , Mohraz, Minoo Department of Infectious Diseases - Tehran University of Medical Sciences, Tehran , Mansouri, Davood Shahid Beheshti University of Medical Sciences, Tehran , Alavi Naini, Roya Department of Infectious Diseases - Zahedan University of Medical Sciences, Zahedan , Kouhpayeh, Hamid Reza Department of Infectious Diseases - Zahedan University of Medical Sciences, Zahedan , Naderi, Mohammad Department of Infectious Diseases - Zahedan University of Medical Sciences, Zahedan , Orchidce Filipe Santos, University of Paris Rene Descartes INSERMU550 - Necker Medical School - Paris, France , Vogt, Guillaume University of Paris Rene Descartes INSERMU550 - Necker Medical School - Paris, France , Chapgicr, Ariane University of Paris Rene Descartes INSERMU550 - Necker Medical School - Paris, France , Feinberg, Jacqueline University of Paris Rene Descartes INSERMU550 - Necker Medical School - Paris, France , Casanova, Jean Laurent University of Paris Rene Descartes INSERMU550 - Necker Medical School - Paris, France , Naserpoor, Taghi Department of Microbiology - Zahedan University of Medical Sciences, Zahedan
Abstract :
The South eastern region of Iran is an endemic area for salmonellosis. Sometimes
bacteremia due to nontyphoidal salmonella occurs but certain patients are at increased
risk for recurrent bacteremia. The risk of invasive salmonellosis and recurrent
bacteremia is increased in the patients with immunosuppression, especially impaired
cell-mediated immunity, lymphoproliferative diseases and in patients with IL-12
deficiency. In recent years, a series of inherited disorders of IL-12-IFN-γ axis have
been described that predispose affected individuals to disseminated disease caused by
environmental mycobacteria and non-typhoidal salmonella. We report here the first
such patient originating from and living in Iran. The patient was a 26-year-old man,
suffering from IL-12p40 deficiency and presented with recurrent episodes of systemic
salmonellosis. This report indicates that there are patients with inherited defects of the
IL-12-IFN-γ circuit in Iran. We recommended to consider this group of disorders in all
patients with recurrent non-typhoidal salmonella bacteremia, wherever they are found.
Keywords :
Immunologic Deficiency Syndromes , Interleukin-12 , Iran , Salmonellosis
