Author/Authors :
Fazlollahi, Mohammad Reza Department of Allergy and Clinical Immunology of Children Medical Center - Tehran University of Medical Sciences, Tehran , Farhoudi, Abolhassan Department of Allergy and Clinical Immunology of Children Medical Center - Tehran University of Medical Sciences, Tehran , Movahedi, Masoud Department of Allergy and Clinical Immunology of Children Medical Center - Tehran University of Medical Sciences, Tehran , Gharagozlou, Mohammad Department of Allergy and Clinical Immunology of Children Medical Center - Tehran University of Medical Sciences, Tehran , Mohammadi, Kourosh Department of Allergy and Clinical Immunology of Children Medical Center - Tehran University of Medical Sciences, Tehran , Rezaei, Nima Department of Allergy and Clinical Immunology of Children Medical Center - Tehran University of Medical Sciences, Tehran
Abstract :
Chronic Mucocutaneous Candidiasis (CMCC) refers to a group of
immunodeficiencies, characterized by persistent or recurrent infections of the skin,
nails, and mucus membranes caused by candida. A wide range of immunologic
abnormality has been reported in CMCC. Defects in cellular limb of the immune
system, mainly the specific response to antigens of candida species, are well
documented in CMCC patients. A subgroup of patients is predisposed to development
of autoimmune endocrinopathies. These patients need repeated monitoring of
endocrine functions. Immunologic studies are needed to identify the extent of
immunodeficiency and other abnormalities of immune functions. We report three cases
of CMCC. These patients show different phenotypes and highlight the need for
complete evaluation and long term follow-up for accompanying disorders.
