Author/Authors :
Hosseini-Farahabadi, Sara Department of Immunogenetics - Bu-Ali Research Institute, Mashhad , Tavakkol-Afshari, Jalil Department of Immunogenetics - Bu-Ali Research Institute, Mashhad , Ganjali, Rashin Department of Immunogenetics - Bu-Ali Research Institute, Mashhad , Rafatpanah, Houshang Department of Allergy and Clinical Immunology - Ghaem Medical Center - Mashhad University of Medical Sciences (MUMS), Mashhad , Ghaffari, Javad Department of Pediatrics - Mazandaran University of Medical Sciences, Sari , Farid-Hosseini, Reza Department of Allergy and Clinical Immunology - Ghaem Medical Center - Mashhad University of Medical Sciences (MUMS), Mashhad
Abstract :
Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria
is supposed to have immune basis causes. It is speculated that the promoter polymorphism
of TGF-β1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of
the population and often can be severe and difficult to treat.
A total of 40 patients with ICU and 41 normal subjects were studied. DNA was extracted
from whole blood and TGF-β1 promoter –509C>T polymorphism was determined by PCRRFLP
method.
Out of the 40 patients with ICU, 11 (27.5%) had CC, 26 (65%) had CT and 3 (7.5%) had
TT genotypes. A higher proportion of case subjects with the C allele (CT type or CC type)
was found compared with the T allele.
These results do suggest an influence of genetic variability at the promoter of TGF-β1
gene (-509C>T) on the occurrence of ICU. This polymorphism has been shown as a useful
genetic change in our study. Further work is required to confirm this result.
