Author/Authors :
Moin, Athar Department of Dermatology - Faculty of Medicine - Shahed University, Tehran , Farhoudi, Abolhassan Department of Allergy and Clinical immunology of Children’s Medical center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Moin, Mostafa Department of Allergy and Clinical immunology of Children’s Medical center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Pourpak, Zahra Department of Allergy and Clinical immunology of Children’s Medical center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Bazargan, Nasrin Department of Pediatric - Faculty of Medicine - Kerman University, Kerman
Abstract :
Primary immunodeficiency diseases (PIDs) are rare but include severe conditions
found predominantly in children, Most PIDs have cutaneous manifestations that may be
important as early diagnostic features.
The purpose of this study was to determine the frequency and nature of cutaneous
alterations associated with PIDs.
This article is a cross-sectional study at the department of allergy and clinical
immunology of children’s medical center conducted between December 5, 2001 and
April 20, 2002. The subjects included pediatric patients with a diagnosis of PID and
dermatological diagnoses were made by a dermatologist.
Two hundred and ten patients were studied They consisted of 68 cases of humoral
deficiency, 22 cases of cellular and combined deficiencies, 57 cases of phagocytic defects
and 63 cases of other PIDs. In 67 cases (31.8%) the cutaneous alterations preceded and
were the basis for clinical immunological diagnosis. Overall cutaneous alterations were
infections in 99 cases and eczematous dermatitis in 27 cases.
Our findings support the results of other studies that most PIDs have cutaneous
features which being their typical aspects are highly suggestive for the diagnosis of PIDs.
