Author/Authors :
Abediankenari, Saeid Department of Pathobiology - Division of Immunology - School of Public Health - Tehran University of Medical Sciences, Tehran , Eslami, Mohammad Bagher Department of Pathobiology - Division of Immunology - School of Public Health - Tehran University of Medical Sciences, Tehran , Sarrafnejad, Abdolfattah Department of Pathobiology - Division of Immunology - School of Public Health - Tehran University of Medical Sciences, Tehran , Mohseni, Mehrnosh Tehran University of Medical Sciences, Tehran , Larijani, Bagher Tehran University of Medical Sciences, Tehran
Abstract :
HLA-G is normally expressed on human trophoblast cells. It is a non-classical MHC
molecule class I b. The role of HLA-G in diabetic type 1 is not known.
We investigated the role of IFN-β in induction HLA-G expression on the monocyte
derived dendritic cells (DC) in diabetes type 1.
Treatment of dendritic cell with IFN-β in vitro from diabetic patients (n=20) and normal
subjects (n=20) resulted to the production and expression of HLA-G on these cells from both
groups. However, comparison of DC from the diabetic patients with DC from the controls
revealed lower levels of HLA-G molecules in DC from diabetic patients. Using mixed
lymphocyte reaction (MLR), it was found that DC expressing HLA-G mediated the inhibition
of autologous T cell activation.
It is concluded that IFN-β can increase HLA-G in DC from diabetic patients; subsequently
it may prevent the immune regularly pathway in the diabetic pathogenesis.
Keywords :
Autoimmunity , Diabetes type 1 , Dendritic cell , HLA-G , IFN-β (Interferon β)
