Breast Cancer and Paradigm of Genomic Instability

Genome instability could be defined as an elevated tendency for the genome to acquire genetic alterations; ranging from changes to the nucleotide sequence to chromosomal gain, loss or rearrangements. Accumulating evidence indicates that cell transformation is associated with genome instability leading to an imbalance between the mechanisms of cell-cycle control and mutation rates within the genes. Genomic instability is broadly classified into microsatellite instability (MIN) associated with mutated phenotype, and chromosome instability (CIN) expressed as gross chromosomal abnormalities